Dianne Frazier, PhD, MPH, RD
Professor Emeritus
UNC School of Medicine

The Genetic Metabolic Dietitians International (GMDI) completed the Guidelines for the Nutritional Management of MSUD in 2013. With the help of a grant from the MSUD Family Support Group, the GMDI workgroup surveyed both the MSUD community and metabolic dietitians to determine the unmet needs for educational resources.

Using this needs assessment, the MSUD Toolkit was designed to provide a practical guide to assist clinicians implementing the Guidelines. Linked to the toolkit are resources developed or adapted for use with this population. One of these is a food list containing the leucine and protein content of foods appropriate for individuals limiting their leucine intake. This was a resource requested by nearly 100% of the survey respondents. It is now available online to be downloaded, printed, or searched at Leucine-and-Protein-Content-of-Foods. The instructions for these functions are on the website.

The nutritional information was obtained from the GMDI nutrient analysis software MetabolicPro. Once the entire toolkit is published, clinicians will be able to access, and modify if necessary, other resources they deem appropriate for specific individuals with MSUD.


The MSUD Family Support Group is currently funding several research projects and we are proactively looking for researchers interested in developing new treatments or finding a cure for MSUD. Significant funding is necessary if we are to accomplish this goal.
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