1. FOOD POISONING: It is well known that a large percentage of episodes of vomiting and diarrhea are really food poisoning and not the "flu" that is often blamed. For children and persons with MSUD, the vomiting and diarrhea that go with food poisoning can be disastrous. Be sure all foods that are to be refrigerated are not left at room temperature after a meal. Keep formula refrigerated between feedings. Keep dishes washed and use good hygiene. You may be able to avoid flu-like episodes that send MSUD children to the hospital.
  2. ASPIRIN: Do not give aspirin or over-the-counter medications containing aspirin to children with MSUD. Children with MSUD are very susceptible to a Reye Syndrome-like illness with the accompanying brain edema. It is very important that children with MSUD do not take aspirin or products containing aspirin. Make it a practice to read the ingredient list on all over-the-counter medications.
  3. VALPROIC ACID (valproate): Additional research is needed to determine the safety of medication containing valproate for children with MSUD. Valproic acid has been given to some children with MSUD for seizure activity. Several parents have noted significant changes in their children when this medication was given. These reactions disappeared when the medication was withdrawn. (See previous article and abstract.)

Have you noticed any adverse reactions to medications in your child with MSUD? Has any adult with MSUD had reactions? The editor would be interested in hearing from you and also from professionals who could give us some insight into medications and MSUD.


The MSUD Family Support Group is currently funding several research projects and we are proactively looking for researchers interested in developing new treatments or finding a cure for MSUD. Significant funding is necessary if we are to accomplish this goal.
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