- Associate Professor, U.T. Southwestern Medical Center
- Science Advisory Board
Most of his research career has been spent working on protein purification, isolation and characterization of macromolecular complexes and protein crystallization. In 2010, he began to explore small molecule drug discovery in order to produce kinase inhibitors for the mitochondrial BCKDC kinase (BDK) and the pyruvate dehydrogenase kinases. He has used structure-based design to develop a new generation of small-molecule inhibitors specific to BDK and pan-PDK’s. These kinase inhibitors have shown good promise in promoting oxidation of glucose and of branched-chain amino acids, while reducing lipogenesis in animal models for obesity and type 2 diabetes.